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It is 1906, and in New York the Italian crime group known as the Black Hand is on a spree of kidnapping, extortion and arson. Detective Isaac Bell of the Van Dorn Agency is hired to form a special Black Hand Squad, but the gangsters appear to be everywhere. Then the murders begin, each one of a man more powerful than the last, and as Bell discovers, to his dismay, the ultimate target may be the most powerful man of all.